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flavin te

FLAVIN TE

Transepithelial Riboflavin Ophthalmic Solution

Flavin TE is a sterile, preservative-free ophthalmic solution containing Riboflavin 0.25% and dextran in Saline with EDTA & Tromethamine. They are used as a photo sensitizing agent in Corneal Collagen cross linking as a treatment for patients with Keratoconus and Corneal Ectasia in different corneal conditions.

eIFU Publication

Advantages of Cross Linking Treatment with Flavin TE

Causes an increase in corneal stiffness of the anterior 200-250 um

Cross- linking effects are directed to the anterior Cornea because of Flavin’s high UV-A absorption capacity. Thus Corneal Endothelium, Lens and Retina will be protected

Dextran in FLAVIN helps

Maintains the Osmolarity

Avoids corneal soaking and swelling during the treatment

Halts the progress and causes some regression.

No injection, no stitches & no incisions as in Keratoplasty

Quick & Easy treatment with low costs

FEATURES

Flavin TE, a Transepithelial Riboflavin Ophthalmic Solution emerges as a pioneering solution in the realm of ophthalmology, specifically crafted for corneal collagen cross-linking. This sterile and preservative-free formulation encapsulates the potent combination of Riboflavin 0.25% and dextran in Saline, fortified with EDTA & Tromethamine.

Designed as a photo-sensitizing agent, Flavin TE holds promise as a treatment modality for patients diagnosed with Keratoconus and Corneal Ectasia across various corneal conditions. This sterile, preservative-free formulation represents a significant advancement in ophthalmic care, offering targeted treatment and restoration of ocular health.

INGREDIENTS

Riboflavin Sodium Phosphate BP (Equivalent to base Riboflavin) – 0.25% w/v: Riboflavin serves as the primary active component responsible for initiating cross-linking within the corneal collagen fibers.

  • Dextran P500 – 15% w/v: Dextran aids in maintaining corneal osmolarity, providing lubrication during the treatment process, and enhancing patient comfort and compliance.
  • Phosphate Buffer Saline (q.s.): The Phosphate Buffer Saline acts as a stabilizing agent, maintaining pH balance and ensuring formulation compatibility. It enhances the stability and shelf-life of Flavin TE, safeguarding its therapeutic integrity.
  • EDTA, Tromethamine (TRIS): EDTA and Tromethamine serve as chelating agents and buffering agents, respectively, contributing to the formulation’s stability and compatibility. They reinforce Flavin TE’s safety profile and ensure its efficacy in corneal collagen cross-linking.
  • Hypromellose – 12mg: Hypromellose, also known as hydroxypropyl methylcellulose, is a polymer derivative of cellulose. It serves various functions within Flavin TE, including enhancing viscosity, providing lubrication, and improving the retention of the solution on the ocular surface.

OPERATIONS

Biotech Flavin TE is used primarily in Corneal Collagen Cross-Linking (CXL) procedures. These procedures are crucial for treating conditions like Keratoconus and Corneal Ectasia, where the cornea becomes thin and distorted.

During Corneal Collagen Cross-Linking (CXL) procedures, Flavin TE’s targeted action ensures that only the cornea is affected, minimizing damage to other eye structures. By using Flavin TE in Corneal Collagen Cross-Linking (CXL) procedures eye surgeons can offer patients a safe, effective, and minimally invasive treatment option for these conditions.

  • Sterile and Preservative-Free Formulation: Flavin TE is meticulously prepared to ensure optimal safety and efficacy, providing patients with a sterile and preservative-free solution for enhanced ocular health.
  • Riboflavin 0.25% and Dextran Combination: The inclusion of Riboflavin 0.25% and dextran in Saline with EDTA & Tromethamine enables targeted cross-linking effects on the anterior cornea, promoting corneal stabilization and structural integrity.
  • Selective Cross-Linking Action: Flavin TE’s unique formulation facilitates selective cross-linking effects on the anterior cornea, minimizing collateral damage to surrounding ocular structures while maximizing therapeutic efficacy.
  • Osmolarity Maintenance: The presence of dextran in Flavin TE aids in the maintenance of corneal osmolarity, preventing corneal soaking and swelling during treatment sessions and ensuring patient comfort throughout the procedure.
  • Non-Invasive Treatment Modality: Unlike traditional interventions such as Keratoplasty, Flavin TE offers a non-invasive treatment modality that eliminates the need for injections, stitches, or incisions, enhancing patient comfort and acceptance.
  • Cost-Effective and Expedient: Flavin TE presents a cost-effective and expedient treatment option for patients and healthcare providers alike, streamlining the treatment process and reducing associated costs without compromising on therapeutic efficacy.

Technical Specifications

Flavin TETransepithelial Riboflavin Ophthalmic Solution (0.25%)
COMPOSITIONEach ml contains

Riboflavin Sodium Phosphate BP

(Equivalent to base Riboflavin)……………………0.25% w/v

Dextran P500 ……………………………………………15% w/v

Phoshpate Buffar Saline………………………………q. s.

EDTA, Tromethamine (TRIS)

SUPPLY

Flavin TE is supplied in ready to single use sterile Prefilled Syringe of 1.0 ml with sterile single use Cannula.

Flavin TE can be supplied with filled volume of 3.0 ml for special orders.

SURGERY VIDEO

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Battig Treuhand AG
Obergrundstrasse 17,
6002, Luzern,
Switzerland

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